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The Sound of Evolution
Propafenone
Mechanism of action:
Propafenone is a class IC sodium channel blocker. Propafenone binds to voltage-gated Na+ channels on the membrane of cardiomyocytes, markedly reduces the phase 0 depolarization rate, and significantly slows cardiac conduction, while having a relatively small effect on action potential duration.
Reference(s):
1. Edrich T et al. (2005). State-dependent block of human cardiac hNav1.5 sodium channels by propafenone. J Membr Biol.
2. Mergenthaler J et al. (2001). Blocking effects of the antiarrhythmic drug propafenone on the HERG potassium channel. Naunyn Schmiedebergs Arch Pharmacol.
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