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Propantheline


Mechanism of action:

Propantheline is a muscarinic acetylcholine receptor antagonist. Propantheline binds to M1, M2, and M3 muscarinic acetylcholine receptors in peripheral tissues and competitively blocks the action of acetylcholine released from parasympathetic nerve endings in those tissues. In the stomach and intestines, blockade of muscarinic receptors reduces smooth muscle tone and leads to decreased intestinal motility.

Reference(s):

1. Lukacs VA et al. (1989). [Antiperspirants and deodorants--ingredients and evaluation]. Derm Beruf Umwelt. 


2. Saitoh H et al. (1986). Interaction of tertiary amines and quaternary ammonium compounds with gastrointestinal mucin. J Pharmacobiodyn. 


3. Trkulja V et al. (2004). Involvement of the peripheral cholinergic muscarinic system in the compensatory ovarian hypertrophy in the rat. Exp Biol Med (Maywood).

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