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The Sound of Evolution
Protriptyline
Mechanism of action:
Protriptyline is a tricyclic antidepressant (TCA). Protriptyline primarily inhibits the norepinephrine transporter, increasing the concentration of norepinephrine in the synaptic cleft and enhancing noradrenergic activity in the central nervous system. Protriptyline has a weaker inhibitory effect on the serotonin transporter.
Reference(s):
1. Tatsumi M et al. (1997). Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol.
2. Cheetham SC et al. (1996). [3H]nisoxetine--a radioligand for noradrenaline reuptake sites: correlation with inhibition of [3H]noradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatments. Neuropharmacology.
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