The Sound of Evolution
Pyridostigmine
Mechanism of action:
Pyridostigmine is an acetylcholinesterase inhibitor and belongs to the carbamate derivatives. Pyridostigmine binds to the active site of acetylcholinesterase, temporarily impairing its ability to break down acetylcholine. As a result, the concentration of acetylcholine in the synaptic cleft increases, thereby enhancing signal transmission at the neuromuscular junction.
Reference(s):
1. Singer W et al. (2003). Acetylcholinesterase inhibition: a novel approach in the treatment of neurogenic orthostatic hypotension. J Neurol Neurosurg Psychiatry.
2. Gilhus NE et al. (2015). Myasthenia gravis: subgroup classification and therapeutic strategies. Lancet Neurol.
3. Rodriguez Cruz PM et al. (2018). The Neuromuscular Junction and Wide Heterogeneity of Congenital Myasthenic Syndromes. Int J Mol Sci.