The Sound of Evolution
Quinapril
Mechanism of action:
Quinapril is an angiotensin-converting enzyme inhibitor. After hepatic hydrolysis in the body, quinapril is converted into its active form, quinaprilat, which inhibits the function of angiotensin-converting enzyme. Angiotensin-converting enzyme is responsible for converting angiotensin I into angiotensin II, thereby promoting vasoconstriction and increasing blood pressure. When quinaprilat inhibits angiotensin-converting enzyme, the amount of angiotensin II decreases, reducing vasoconstrictive signaling and lowering hemodynamic load.
Reference(s):
1. Kieback AG et al. (2009). Quinaprilat: a review of its pharmacokinetics, pharmacodynamics, toxicological data and clinical application. Expert Opin Drug Metab Toxicol.
2. Tsikouris JP et al. (2004). Questioning a class effect: does ACE inhibitor tissue penetration influence the degree of fibrinolytic balance alteration following an acute myocardial infarction? J Clin Pharmacol.