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The Sound of Evolution
Ramelteon
Mechanism of action:
Ramelteon is a selective melatonin receptor agonist. Ramelteon activates MT1 and MT2 melatonin receptors in the suprachiasmatic nucleus of the hypothalamus. The MT1 receptor promotes sleep onset and suppresses wake-promoting signals, whereas the MT2 receptor regulates and synchronizes circadian rhythm.
Reference(s):
1. Karim A et al. (2006). Disposition kinetics and tolerance of escalating single doses of ramelteon, a high-affinity MT1 and MT2 melatonin receptor agonist indicated for treatment of insomnia. J Clin Pharmacol.
2. Miyamoto M et al. (2009). Pharmacology of ramelteon, a selective MT1/MT2 receptor agonist: a novel therapeutic drug for sleep disorders. CNS Neurosci Ther.
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