The Sound of Evolution
Ramipril
Mechanism of action:
Ramipril is an angiotensin-converting enzyme inhibitor. After hepatic hydrolysis in the body, ramipril is converted into its active form, ramiprilat, which inhibits the function of angiotensin-converting enzyme. Angiotensin-converting enzyme is responsible for converting angiotensin I into angiotensin II, thereby promoting vasoconstriction and increasing blood pressure. When ramiprilat inhibits angiotensin-converting enzyme, the amount of angiotensin II decreases, reducing vasoconstrictive signaling and lowering hemodynamic load.
Reference(s):
1. Cacciapuoti F et al. (1998). Prevention of left ventricular hypertrophy by ACE-inhibitor, ramipril in comparison with calcium-channel antagonist, felodipine. Int J Cardiol.
2. Kleinert S et al. (1999). HOPE for cardiovascular disease prevention with ACE-inhibitor ramipril. Lancet.
3. Douros A et al. (2013). Ramipril-induced liver injury: case report and review of the literature. Am J Hypertens.