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Ramosetron


Mechanism of action:

Ramosetron is a selective serotonin 5-HT3 receptor antagonist. When chemotherapy or anesthesia stimulates the gastrointestinal mucosa, enterochromaffin cells release large amounts of serotonin (5-HT), which acts on vagal nerve terminals and the chemoreceptor trigger zone (CTZ) in the medulla, causing nausea and vomiting. Ramosetron competitively antagonizes 5-HT3 receptors, preventing serotonin from activating these neural pathways and thereby suppressing the nausea and vomiting reflex.

Reference(s):

1. Fujii Y et al. (2000). Ramosetron for preventing postoperative nausea and vomiting in women undergoing gynecological surgery. Anesth Analg. 


2. Lee SH et al. (2016). Population pharmacokinetics of ramosetron. J Pharmacokinet Pharmacodyn.

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