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The Sound of Evolution
Ranitidine
Mechanism of action:
Ranitidine is an H2 receptor antagonist. Ranitidine binds to H2 receptors on the basolateral membrane of gastric parietal cells and blocks histamine-mediated receptor activation, thereby inhibiting the Gs-adenylyl cyclase-cAMP pathway, reducing H+/K+-ATPase activity, and decreasing gastric acid secretion.
Reference(s):
1. Mauran A et al. (2016). Mania associated with ranitidine: a case report and review of literature. Fundam Clin Pharmacol.
2. Grant SM et al. (1989). Ranitidine. An updated review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in peptic ulcer disease and other allied diseases. Drugs.
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