The Sound of Evolution
Rasagiline
Mechanism of action:
Rasagiline is a selective monoamine oxidase-B inhibitor. Monoamine oxidase-B is one of the main enzymes responsible for breaking down dopamine in the brain. After rasagiline covalently binds to monoamine oxidase-B, the enzyme loses its activity, causing dopamine levels in the synaptic cleft to rise and enhancing dopaminergic signaling in the striatum.
Reference(s):
1. Weinreb O et al. (2010). Rasagiline: a novel anti-Parkinsonian monoamine oxidase-B inhibitor with neuroprotective activity. Prog Neurobiol.
2. Leegwater-Kim J et al. (2010). The role of rasagiline in the treatment of Parkinson's disease. Clin Interv Aging.
3. Chen JJ et al. (2007). Comprehensive review of rasagiline, a second-generation monoamine oxidase inhibitor, for the treatment of Parkinson's disease. Clin Ther.