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The Sound of Evolution
Rasburicase
Mechanism of action:
Rasburicase is a recombinant urate oxidase. Rasburicase converts uric acid into allantoin, which is highly water-soluble and can be rapidly excreted by the kidneys.
Reference(s):
1. Collings I et al. (2010). Polymorphism of microcrystalline urate oxidase from Aspergillus flavus. Acta Crystallogr D Biol Crystallogr.
2. Giraldez M et al. (2010). A single, fixed dose of rasburicase (6 mg maximum) for treatment of tumor lysis syndrome in adults. Eur J Haematol.
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