top of page
< Back

Reboxetine


Mechanism of action:

Reboxetine is a selective norepinephrine reuptake inhibitor. Reboxetine binds to the norepinephrine transporter on the presynaptic neuronal membrane and blocks the reuptake of norepinephrine from the synaptic cleft into the nerve terminal. This increases norepinephrine concentration in the synaptic cleft and enhances its effects.

Reference(s):

1. Fleishaker JC et al. (2000). Clinical pharmacokinetics of reboxetine, a selective norepinephrine reuptake inhibitor for the treatment of patients with depression. Clin Pharmacokinet. 


2. Edwards DM et al. (1995). Pharmacokinetics of reboxetine in healthy volunteers. Single oral doses, linearity and plasma protein binding. Biopharm Drug Dispos.

bottom of page