The Sound of Evolution
Reserpine
Mechanism of action:
Reserpine is an indole alkaloid. Reserpine enters neurons and irreversibly inhibits VMAT2 (vesicular monoamine transporter 2), preventing neurotransmitters from being transported into synaptic vesicles. Because these neurotransmitters can no longer be stored in vesicles, they are degraded in the cytoplasm by monoamine oxidase. Depletion of norepinephrine leads to reduced cardiac output and lower blood pressure. Depletion of dopamine and serotonin (5-HT) produces effects related to sedation and depressed mood.
Reference(s):
1. Chobanian AV et al. (2003). The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA.
2. Moser M et al. (1987). "Cost containment" in the management of hypertension. Ann Intern Med.