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The Sound of Evolution
Reteplase
Mechanism of action:
Reteplase is a recombinant tissue plasminogen activator. After binding to fibrin within a thrombus, reteplase catalyzes the conversion of plasminogen into plasmin. Activated plasmin hydrolyzes fibrin, fibrinogen, and other coagulation-related proteins, thereby disrupting thrombus structure and restoring vessel patency.
Reference(s):
1. Hilleman DE et al. (2007). Fibrinolytic agents for the management of ST-segment elevation myocardial infarction. Pharmacotherapy.
2. Longstaff C et al. (2008). Fibrin binding and the regulation of plasminogen activators during thrombolytic therapy. Cardiovasc Hematol Agents Med Chem.
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