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The Sound of Evolution
Rifaximin
Mechanism of action:
Rifaximin is a rifamycin antibiotic. Rifaximin binds with high affinity to the beta subunit of bacterial RNA polymerase, blocking the initiation of RNA elongation. As a result, mRNA cannot be produced, and all protein synthesis is inhibited.
Reference(s):
1. Cottreau J et al. (2010). Rifaximin: a nonsystemic rifamycin antibiotic for gastrointestinal infections. Expert Rev Anti Infect Ther.
2. Williams R et al. (2005). Rifaximin, a nonabsorbed oral antibiotic, in the treatment of hepatic encephalopathy: antimicrobial activity, efficacy, and safety. Rev Gastroenterol Disord.
3. Koo HL et al. (2010). Rifaximin: a unique gastrointestinal-selective antibiotic for enteric diseases. Curr Opin Gastroenterol.
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