The Sound of Evolution
Rimegepant
Mechanism of action:
Rimegepant is a calcitonin gene-related peptide receptor antagonist. The calcitonin gene-related peptide receptor is a receptor complex composed of the calcitonin receptor-like receptor and receptor-activity-modifying protein 1. When rimegepant binds to this receptor, it blocks calcitonin gene-related peptide-induced intracranial vasodilation, neurogenic inflammation, and amplification of pain signaling.
Reference(s):
1. Lipton RB et al. (2019). Rimegepant, an Oral Calcitonin Gene-Related Peptide Receptor Antagonist, for Migraine. N Engl J Med.
2. Negro A et al. (2019). Gepants for the treatment of migraine. Expert Opin Investig Drugs.
3. Martelletti P et al. (2019). Advances in orally administered pharmacotherapy for the treatment of migraine. Expert Opin Pharmacother.