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The Sound of Evolution
Rocuronium
Mechanism of action:
Rocuronium is a non-depolarizing aminosteroid neuromuscular blocker. Rocuronium binds inhibitory to nicotinic acetylcholine receptors on the motor end-plate and blocks acetylcholine-induced depolarization, producing reversible skeletal muscle relaxation and paralysis.
Reference(s):
1. Agoston S et al. (1992). Clinical pharmacokinetics of neuromuscular blocking drugs. Clin Pharmacokinet.
2. Khuenl-Brady KS et al. (1996). Clinical pharmacokinetics of rocuronium bromide. Clin Pharmacokinet.
3. Alvarez-Gomez JA et al. (1997). [Rocuronium]. Rev Esp Anestesiol Reanim.
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