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The Sound of Evolution
Rofecoxib
Mechanism of action:
Rofecoxib is a selective cyclooxygenase-2 inhibitor. Rofecoxib inhibits cyclooxygenase-2, or COX-2, thereby blocking the conversion of arachidonic acid into prostaglandins and prostacyclin, and reducing inflammation, pain, and fever.
Reference(s):
1. Bombardier C et al. (2000). Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. N Engl J Med.
2. Bresalier RS et al. (2005). Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. N Engl J Med.
3. Curfman GD et al. (2006). Expression of concern reaffirmed. N Engl J Med.
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