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The Sound of Evolution
Ropinirole
Mechanism of action:
Ropinirole is a dopamine receptor agonist. Ropinirole has relatively high affinity for D2 and D3 receptors. After receptor activation, it inhibits adenylyl cyclase through Gi/o protein coupling, lowers cAMP levels, and reduces excessive activation of inhibitory output nuclei such as the globus pallidus internus.
Reference(s):
1. Matheson AJ et al. (2000). Ropinirole: a review of its use in the management of Parkinson's disease. Drugs.
2. Nashatizadeh MM et al. (2009). A review of ropinirole prolonged release in Parkinson's disease. Clin Interv Aging.
3. Kushida CA et al. (2006). Ropinirole for the treatment of restless legs syndrome. Neuropsychiatr Dis Treat.
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