top of page
The Sound of Evolution
Salmeterol
Mechanism of action:
Salmeterol is a selective beta2-adrenergic agonist. Salmeterol binds to and activates beta2-adrenergic receptors on bronchial smooth muscle, activates Gs protein, stimulates adenylyl cyclase activity, and increases cAMP levels. This causes smooth muscle relaxation and produces bronchodilation.
Reference(s):
1. Cazzola M et al. (2002). Clinical pharmacokinetics of salmeterol. Clin Pharmacokinet.
2. Manchee GR et al. (1993). Disposition of salmeterol xinafoate in laboratory animals and humans. Drug Metab Dispos.
bottom of page