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The Sound of Evolution
Secobarbital
Mechanism of action:
Secobarbital is a barbiturate derivative. Secobarbital binds to the barbiturate binding site on the GABA_A receptor complex, prolongs the opening time of the chloride channel, increases Cl- influx, causes neuronal hyperpolarization, and markedly suppresses neuronal firing.
Reference(s):
1. Yamakura T et al. (2001). Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol.
2. Mehta AK et al. (1999). An update on GABAA receptors. Brain Res Brain Res Rev.
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