The Sound of Evolution
Semaglutide
Mechanism of action:
Semaglutide is a glucagon-like peptide-1 receptor agonist. By binding to GLP-1 receptors on pancreatic beta cells, semaglutide promotes glucose-dependent insulin secretion, while also suppressing glucagon release, delaying gastric emptying, and reducing appetite, thereby lowering both postprandial and fasting glucose-related burden.
Reference(s):
1. Gotfredsen CF et al. (2014). The human GLP-1 analogs liraglutide and semaglutide: absence of histopathological effects on the pancreas in nonhuman primates. Diabetes.
2. Blundell J et al. (2017). Effects of once-weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight in subjects with obesity. Diabetes Obes Metab.
3. Lee YS et al. (2014). Anti-diabetic actions of glucagon-like peptide-1 on pancreatic beta-cells. Metabolism.