The Sound of Evolution
Sertraline
Mechanism of action:
Sertraline is a selective serotonin reuptake inhibitor and a phenylamine derivative. Sertraline binds with high affinity to the serotonin transporter on the presynaptic neuronal membrane, blocks the reuptake of serotonin, or 5-HT, from the synaptic cleft back into the neuron, increases serotonin concentration in the synaptic cleft, and enhances serotonergic activity.
Reference(s):
1. Fabre LF et al. (1995). Sertraline safety and efficacy in major depression: a double-blind fixed-dose comparison with placebo. Biol Psychiatry.
2. Kronig MH et al. (1999). Placebo-controlled, multicenter study of sertraline treatment for obsessive-compulsive disorder. J Clin Psychopharmacol.
3. Brady K et al. (2000). Efficacy and safety of sertraline treatment of posttraumatic stress disorder: a randomized controlled trial. JAMA.