The Sound of Evolution
Streptomycin
Mechanism of action:
Streptomycin is an aminoglycoside antibiotic (aminoglycoside antibiotic). Streptomycin binds to the 16S rRNA and S12 protein of the bacterial 30S ribosomal subunit, interfering with the normal formation of the translation initiation complex. It also causes the ribosome to misread mRNA codons, leading to the incorporation of incorrect amino acids into proteins and the production of structurally abnormal, dysfunctional proteins.
Reference(s):
1. Adeyemo AA et al. (2016). Study of streptomycin-induced ototoxicity: protocol for a longitudinal study. Springerplus.
2. Laurell G et al. (2019). Pharmacological intervention in the field of ototoxicity. HNO.
3. Serio AW et al. (2018). Aminoglycoside Revival: Review of a Historically Important Class of Antimicrobials Undergoing Rejuvenation. EcoSal Plus.