The Sound of Evolution
Succimer
Mechanism of action:
Succimer is a heavy metal chelating agent (heavy metal chelating agent), chemically known as dimercaptosuccinic acid (DMSA). The succimer molecule contains two sulfhydryl groups (-SH), which can form stable cyclic chelation structures with metal ions such as lead (Pb2+), mercury (Hg2+), and arsenic (As3+), thereby reducing the damage these metal ions cause to the nervous system, hematopoietic system, and kidneys.
Reference(s):
1. Miller AL et al. (1998). Dimercaptosuccinic acid (DMSA), a non-toxic, water-soluble treatment for heavy metal toxicity. Altern Med Rev.
2. Aaseth J et al. (1995). Treatment of mercury and lead poisonings with dimercaptosuccinic acid and sodium dimercaptopropanesulfonate. A review. Analyst.
3. Mann KV et al. (1991). Succimer, an oral lead chelator. Clin Pharm.