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The Sound of Evolution
Sucralfate
Mechanism of action:
Sucralfate is a sulfated sucrose-aluminum complex (sulfated sucrose-aluminum complex). In the low-pH environment of the stomach, sucralfate dissociates and polymerizes to form a highly viscous, negatively charged gel-like substance. This gel binds to exposed proteins at the base of an ulcer and forms a protective covering layer over the ulcer surface.
Reference(s):
1. Rees WD et al. (1991). Mechanisms of gastroduodenal protection by sucralfate. Am J Med.
2. Candelli M et al. (2000). Role of sucralfate in gastrointestinal diseases. Panminerva Med.
3. Lam SK et al. (1990). Why do ulcers heal with sucralfate? Scand J Gastroenterol Suppl.
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