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The Sound of Evolution
Sulconazole
Mechanism of action:
Sulconazole is an imidazole derivative. Sulconazole inhibits fungal lanosterol 14alpha-demethylase (CYP51), the enzyme responsible for converting lanosterol into ergosterol. When this step is blocked, the fungal cell membrane becomes structurally incomplete, and lanosterol accumulates because it cannot be converted, causing toxicity and ultimately inhibiting fungal growth or leading to fungal death.
Reference(s):
1. Franz TJ et al. (1988). Percutaneous absorption of sulconazole nitrate in humans. J Pharm Sci.
2. Holt RJ et al. (1976). Topical pharmacology of imidazole antifungals. J Cutan Pathol.
3. Mazu TK et al. (2016). The Mechanistic Targets of Antifungal Agents: An Overview. Mini Rev Med Chem.
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