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Sulfinpyrazone


Mechanism of action:

Sulfinpyrazone is a uricosuric agent and a pyrazolidinedione derivative. Sulfinpyrazone inhibits uric acid reabsorption transporters in the proximal renal tubules, including urate transporter 1 (URAT1), thereby reducing the reabsorption of uric acid from the tubular lumen back into the blood. This increases uric acid excretion and lowers blood uric acid levels. Sulfinpyrazone also reduces ADP- and thromboxane A2-mediated platelet aggregation.

Reference(s):

1. Didisheim P et al. (1974). Platelet inhibition in the management of thrombosis. Thromb Diath Haemorrh. 


2. Margulies EH et al. (1980). Sulfinpyrazone: a review of its pharmacological properties and therapeutic use. Drugs. 


3. Schrader BJ et al. (1990). Antiplatelet agents in coronary artery disease. Clin Pharm.

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