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The Sound of Evolution
Sulindac
Mechanism of action:
Sulindac is first reduced in the body to its active metabolite, sulindac sulfide. Sulindac sulfide inhibits cyclooxygenase, including COX-1 and COX-2, thereby blocking the conversion of arachidonic acid into prostaglandins and thromboxanes and reducing inflammation and pain perception.
Reference(s):
1. Giuliano F et al. (1999). Ex vivo assay to determine the cyclooxygenase selectivity of non-steroidal anti-inflammatory drugs. Br J Pharmacol.
2. Molina MA et al. (1999). Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. Cancer Res.
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