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The Sound of Evolution
Suramin
Mechanism of action:
Suramin is a polysulfonated naphthylurea compound. Its precise mechanism of action remains unclear, but it is known to inhibit enzymes involved in glycolysis in Trypanosoma brucei, as well as ATP utilization and production pathways, DNA polymerase, and RNA polymerase.
Reference(s):
1. Charlton SJ et al. (1996). PPADS and suramin as antagonists at cloned P2Y- and P2U-purinoceptors. Br J Pharmacol.
2. Bogdanov YD et al. (1998). Molecular cloning and characterization of rat P2Y4 nucleotide receptor. Br J Pharmacol.
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