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The Sound of Evolution
Tacrine
Mechanism of action:
Tacrine is an acetylcholinesterase inhibitor and a tetrahydroaminoacridine derivative. Tacrine reversibly inhibits acetylcholinesterase, thereby slowing the breakdown of acetylcholine in the synaptic cleft and enhancing cholinergic neurotransmission.
Reference(s):
Qizilbash N et al. (1998). Cholinesterase inhibition for Alzheimer disease: a meta-analysis of the tacrine trials. Dementia Trialists' Collaboration. JAMA.
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