top of page
The Sound of Evolution
Tamsulosin
Mechanism of action:
Tamsulosin is a selective a1-adrenergic antagonist. It primarily acts on a1A receptors, which are Gq/11 protein-coupled receptors located in the smooth muscle of the prostate and bladder outlet, and inhibits norepinephrine-induced smooth muscle contraction.
Reference(s):
1. Dunn CJ et al. (2002). Tamsulosin: a review of its pharmacology and therapeutic efficacy in the management of lower urinary tract symptoms. Drugs Aging.
2. Matsushima H et al. (1998). Pharmacokinetics and plasma protein binding of tamsulosin hydrochloride in rats, dogs, and humans. Drug Metab Dispos.
3. Soeishi Y et al. (1996). Absorption, metabolism and excretion of tamsulosin hydrochloride in man. Xenobiotica.
bottom of page