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The Sound of Evolution
Tegaserod
Mechanism of action:
Tegaserod is a selective 5-HT4 receptor partial agonist. It acts on 5-HT4 receptors in enteric parasympathetic nerves and the enteric plexus, increasing the release of acetylcholine, promoting intestinal smooth muscle contraction, and accelerating intestinal motility and transit time.
Reference(s):
1. Beattie DT et al. (2004). The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo. Br J Pharmacol.
2. Talley NJ et al. (2006). Irritable bowel syndrome. Intern Med J.
3. Borman RA et al. (2002). 5-HT(2B) receptors play a key role in mediating the excitatory effects of 5-HT in human colon in vitro. Br J Pharmacol.
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