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Telbivudine


Mechanism of action:

Telbivudine is a nucleoside reverse transcriptase inhibitor and a thymidine analog. After entering the cell, telbivudine is sequentially phosphorylated by cellular kinases into the active form, telbivudine triphosphate. Telbivudine triphosphate competes with dTTP and is incorporated into viral DNA, inhibiting HBV DNA polymerase or HIV reverse transcriptase, resulting in termination of viral DNA elongation and preventing completion of viral replication.

Reference(s):

1. Matthews SJ et al. (2007). Telbivudine for the management of chronic hepatitis B virus infection. Clin Ther. 


2. Amarapurkar DN et al. (2007). Telbivudine: a new treatment for chronic hepatitis B. World J Gastroenterol. 


3. Dusheiko G et al. (2007). Telbivudine for the treatment of chronic hepatitis B. Drugs Today (Barc).

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