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The Sound of Evolution
Telithromycin
Mechanism of action:
Telithromycin is a ketolide antibiotic and a derivative of the macrolide class. It binds simultaneously to domain II and domain V of the 23S rRNA in the bacterial 50S ribosomal subunit, blocking the movement of the nascent peptide chain from the A site to the P site. This stalls the ribosome and prevents normal protein synthesis.
Reference(s):
Clay KD et al. (2006). Brief communication: severe hepatotoxicity of telithromycin: three case reports and literature review. Ann Intern Med.
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