The Sound of Evolution
Temazepam
Mechanism of action:
Temazepam is a benzodiazepine derivative. It binds to the benzodiazepine binding site on GABA_A receptors in the central nervous system, thereby enhancing GABAergic inhibitory effects. When GABA binds to these receptors, chloride ion channels open, causing neuronal membrane hyperpolarization, reducing neuronal excitability, and suppressing excessive activation in the limbic system and cerebral cortex.
Reference(s):
1. Rickels K et al. (1986). The clinical use of hypnotics: indications for use and the need for a variety of hypnotics. Acta Psychiatr Scand Suppl.
2. Oelschlager H et al. (1989). [Chemical and pharmacologic aspects of benzodiazepines]. Schweiz Rundsch Med Prax.
3. Vozeh S et al. (1981). [Pharmacokinetic of benzodiazepines in old age]. Schweiz Med Wochenschr.