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The Sound of Evolution
Tenoxicam
Mechanism of action:
Tenoxicam is an oxicam derivative. Tenoxicam inhibits cyclooxygenase, including both COX-1 and COX-2, thereby blocking the conversion of arachidonic acid into prostaglandins and reducing prostaglandin-mediated inflammatory signaling, pain sensitization, and fever responses.
Reference(s):
1. Kothekar V et al. (2001). Recognition of cyclooxygenase-2 (COX-2) active site by NSAIDs: a computer modelling study. Indian J Biochem Biophys.
2. Yamada M et al. (1997). Prostaglandin E2 production dependent upon cyclooxygenase-1 and cyclooxygenase-2 and its contradictory modulation by auranofin in rat peritoneal macrophages. J Pharmacol Exp Ther.
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