The Sound of Evolution
Terbutaline
Mechanism of action:
Terbutaline is a selective β₂-adrenergic agonist. Terbutaline activates β₂ receptors on bronchial or uterine smooth muscle, leading to Gs protein-coupled activation of adenylate cyclase, increased cAMP levels, subsequent activation of protein kinase A, and ultimately relaxation of bronchial or uterine smooth muscle.
Reference(s):
1. Rhodes MC et al. (2004). Terbutaline is a developmental neurotoxicant: effects on neuroproteins and morphology in cerebellum, hippocampus, and somatosensory cortex. J Pharmacol Exp Ther.
2. Hochhaus G et al. (1992). Pharmacokinetic/pharmacodynamic characteristics of the beta-2-agonists terbutaline, salbutamol and fenoterol. Int J Clin Pharmacol Ther Toxicol.
3. Haahtela T et al. (1991). Comparison of a beta 2-agonist, terbutaline, with an inhaled corticosteroid, budesonide, in newly detected asthma. N Engl J Med.