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The Sound of Evolution
Terconazole
Mechanism of action:
Terconazole is an imidazole derivative. Terconazole inhibits fungal lanosterol 14α-demethylase (CYP51), the enzyme responsible for converting lanosterol into ergosterol. When this step is blocked, the fungal cell membrane becomes structurally defective, and lanosterol accumulates because it cannot be converted further, leading to toxicity and ultimately suppressing fungal growth or causing fungal cell death.
Reference(s):
1. Thomason JL et al. (1989). Clinical evaluation of terconazole. United states experience. J Reprod Med.
2. Pfaller MA et al. (1989). Susceptibility of clinical isolates of Candida spp. to terconazole and other azole antifungal agents. Diagn Microbiol Infect Dis.
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