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The Sound of Evolution
Teriparatide
Mechanism of action:
Teriparatide is a parathyroid hormone analog and corresponds to the recombinant human PTH 1-34 amino acid fragment. Teriparatide binds to the parathyroid hormone 1 receptor on the surface of osteoblasts in bone, activating the Gs protein-adenylyl cyclase pathway, increasing cAMP levels, and activating protein kinase A. This induces a series of gene expression changes that promote bone formation and osteoblast differentiation.
Reference(s):
1. Stroup J et al. (2008). Teriparatide in the treatment of osteoporosis. Am J Health Syst Pharm.
2. Quattrocchi E et al. (2004). Teriparatide: a review. Clin Ther.
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