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Thiamylal


Mechanism of action:

Thiamylal is a thiobarbiturate derivative. Thiamylal binds to the barbiturate binding site of the GABA_A receptor, enhances the inhibitory effect of GABA, and prolongs the opening time of chloride channels. This increases chloride influx, causes hyperpolarization of the neuronal membrane, and makes neurons less likely to generate action potentials.

Reference(s):

1. Eguchi S et al. (2005). [Effects of propofol and thiamylal on nicorandil induced ATP-sensitive potassium channel activities in cultured rat aortic smooth muscle cells]. Masui. 


2. Kawano T et al. (2004). Molecular mechanisms of the inhibitory effects of propofol and thiamylal on sarcolemmal adenosine triphosphate-sensitive potassium channels. Anesthesiology. 


3. Tsutsumi Y et al. (2000). Blockade of adenosine triphosphate-sensitive potassium channels by thiamylal in rat ventricular myocytes. Anesthesiology.

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