The Sound of Evolution
Thiopental
Mechanism of action:
Thiopental is a thiobarbiturate derivative. Thiopental binds to the barbiturate binding site of the GABA_A receptor, enhances the inhibitory effect of GABA, and prolongs the opening time of chloride channels. This increases chloride influx, causes hyperpolarization of the neuronal membrane, and makes neurons less likely to generate action potentials.
Reference(s):
1. Morgan DJ et al. (1981). Pharmacokinetics and plasma binding of thiopental. II: Studies at cesarean section. Anesthesiology.
2. Winters WD et al. (1955). Metabolism of thiopental-S35 and thiopental-2-C14 by a rat liver mince and identification of pentobarbital as a major metabolite. J Pharmacol Exp Ther.
3. Bory C et al. (1986). [Use of thiopental in man. Determination of this drug and its metabolites in plasma and urine by liquid phase chromatography and mass spectrometry]. C R Acad Sci III.