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The Sound of Evolution
Thiothixene
Mechanism of action:
Thiothixene is a thioxanthene derivative. Thiothixene antagonizes dopamine D₂ receptors in the mesolimbic pathway with high affinity, thereby reducing positive symptoms caused by excessive dopamine activity.
Reference(s):
1. Shultz PJ et al. (1987). Dopaminergic stimulation of cAMP accumulation in cultured rat mesangial cells. Am J Physiol.
2. Oades RD et al. (2000). Neuropsychological and conditioned blocking performance in patients with schizophrenia: assessment of the contribution of neuroleptic dose, serum levels and dopamine D2-receptor occupancy. Behav Pharmacol.
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