The Sound of Evolution
Ticagrelor
Mechanism of action:
Ticagrelor is a platelet P2Y₁₂ receptor antagonist and a triazolopyrimidine derivative. During platelet activation, adenosine diphosphate (ADP) binds to the P2Y₁₂ receptor on the platelet surface, promoting activation and conformational change of the GPIIb/IIIa receptor, which makes it more likely to bind fibrinogen and drive platelet aggregation to form thrombi. Ticagrelor reversibly inhibits the platelet P2Y₁₂ receptor, blocking ADP-mediated signaling and preventing thrombus formation.
Reference(s):
1. Teng R et al. (2010). Absorption, distribution, metabolism, and excretion of ticagrelor in healthy subjects. Drug Metab Dispos.
2. Angheloiu GO et al. (2017). Ticagrelor Removal From Human Blood. JACC Basic Transl Sci.
3. Dorsam RT et al. (2004). Central role of the P2Y12 receptor in platelet activation. J Clin Invest.