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The Sound of Evolution
Ticarcillin
Mechanism of action:
Ticarcillin is a β-lactam antibiotic belonging to the carboxypenicillin class. The β-lactam ring of Ticarcillin binds to penicillin-binding proteins in bacteria and inhibits their transpeptidase activity, preventing cross-linking of peptidoglycan chains. This weakens the bacterial cell wall structure and ultimately causes bacterial lysis and death due to osmotic pressure.
Reference(s):
Chambers HF et al. (1990). Binding affinity for penicillin-binding protein 2a correlates with in vivo activity of beta-lactam antibiotics against methicillin-resistant Staphylococcus aureus. J Infect Dis.
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