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The Sound of Evolution
Tigecycline
Mechanism of action:
Tigecycline is a tetracycline antibiotic. Tigecycline reversibly binds to the 30S subunit of the bacterial ribosome and blocks the binding of aminoacyl-tRNA to the mRNA-ribosome complex, preventing new amino acids from being added to the peptide chain and thereby inhibiting protein synthesis.
Reference(s):
1. Rose WE et al. (2006). Tigecycline: first of a new class of antimicrobial agents. Pharmacotherapy.
2. Kasbekar N et al. (2006). Tigecycline: a new glycylcycline antimicrobial agent. Am J Health Syst Pharm.
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