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Tiludronate


Mechanism of action:

Tiludronate is a bisphosphonate derivative. Tiludronate has a high affinity for hydroxyapatite and preferentially deposits on surfaces undergoing active bone resorption. Within osteoclasts, Tiludronate is metabolized into non-hydrolyzable ATP analogues, which interfere with cellular energy metabolism and ultimately suppress osteoclast function and induce apoptosis.

Reference(s):

1. Sansom LN et al. (1995). Human pharmacokinetics of tiludronate. Bone. 


2. Russell RG et al. (2008). Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy. Osteoporos Int. 


3. Qin A et al. (2012). V-ATPases in osteoclasts: structure, function and potential inhibitors of bone resorption. Int J Biochem Cell Biol.

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