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Tinidazole

Mechanism of action:
Tinidazole is a nitroimidazole antimicrobial agent. After entering microbial cells, tinidazole is reduced by enzyme systems characteristic of anaerobic bacteria or protozoa, such as enzymes associated with ferredoxin. This reduction of the nitro group generates highly reactive free radical intermediates. These free radicals cause DNA strand breakage, preventing normal replication and transcription, ultimately leading to cell death.
Reference(s):
1. Lopez Nigro MM et al. (2008). Genotoxicity and cell death induced by tinidazole (TNZ). Toxicol Lett.
2. Fung HB et al. (2005). Tinidazole: a nitroimidazole antiprotozoal agent. Clin Ther.
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