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The Sound of Evolution
Tinzaparin
Mechanism of action:
Tinzaparin is a low molecular weight heparin. Tinzaparin binds to antithrombin III and enhances its inhibitory effect on coagulation factor Xa. This ultimately reduces fibrin formation and prevents thrombus formation.
Reference(s):
1. Friedel HA et al. (1994). Tinzaparin. A review of its pharmacology and clinical potential in the prevention and treatment of thromboembolic disorders. Drugs.
2. Simonneau G et al. (1997). A comparison of low-molecular-weight heparin with unfractionated heparin for acute pulmonary embolism. The THESEE Study Group. N Engl J Med.
3. Planes A et al. (1999). Prevention of deep vein thrombosis after hip replacement--comparison between two low-molecular heparins, tinzaparin and enoxaparin. Thromb Haemost.
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