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The Sound of Evolution
Tipepidine
Mechanism of action:
Tipepidine is a centrally acting antitussive. Its precise mechanism of action remains unclear, but studies suggest that tipepidine may regulate voltage-gated potassium channels in the cough center of the medulla oblongata, causing neuronal membrane hyperpolarization, reducing neuronal firing frequency, and increasing the threshold for the cough reflex.
Reference(s):
Kawaura K et al. (2012). Pharmacological mechanisms of antidepressant-like effect of tipepidine in the forced swimming test. Behav Brain Res.
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